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In SELECT, semaglutide 2.4 mg subcutaneously weekly reduced MACE by 20% (HR 0.80, 95% CI 0.720.90) with a 1.5% absolute risk reduction over a mean follow-up of 39.8 months [3]

ncbi.nlm.nih.gov/pubmed/11029607 Desaulniers V

Essentially, die off happens when the death of infecting cells creates toxins and an immune reaction as your body tries to remove the toxins

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The sensor had no connected reader, which means that the participants did not receive any feedback on their glucose values